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替格瑞洛杂质标准品 全套供应

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更新时间: 2021-02-23
描述:替格瑞洛杂质标准品 全套供应
图谱证书齐全,纯度高,质量保证,价格优惠,可接定制。
25mg/50mg/100mg等多种规格可选。

产品介绍

品牌自营品牌供货周期现货
应用领域医疗卫生,环保,食品,生物产业

替格瑞洛杂质标准品 全套供应

随货提供:所有杂质对照品均随货提供HPLC,NMR,MS图谱及CoA证书。

杂质定制服务:我司有专业研发团队,可提供杂质定制服务,以大可能的满足您对杂质对照品的选购需求。

替格瑞洛杂质标准品 全套供应

中文名称

英文名称

替格瑞洛标准品

Ticagrelor

替格瑞洛杂质1

(1R,2R,3S,5R)-3-(7-(((1S,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质2

(1S,2S,3R,5S)-3-(7-(((1S,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质3

(1R,2R,3S,5R)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质4

(1S,2S,3R,5S)-3-(7-(((1R,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol compound with (1S,2S,3R,5S)-3-(7-(((1S,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (1:1)

替格瑞洛杂质5

(1R,2R,3S,5R)-3-(7-(((1R,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol compound with (1R,2R,3S,5R)-3-(7-(((1S,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (1:1)

替格瑞洛杂质6

2-(((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl acetate

替格瑞洛杂质7

(1S,2S,3R,5S)-3-(7-hydroxy-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质8

(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质9

2-(((3aR,4S,6R,6aS)-6-((3-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol

替格瑞洛杂质10

5-amino-6-chloro-2-(propylthio)pyrimidin-4-ol

替格瑞洛杂质11

2-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)oxy)ethanol

替格瑞洛杂质12

(1S,2S,3R,5S)-3-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质13

5-amino-6-(((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-2-(propylthio)pyrimidin-4-ol

替格瑞洛杂质14

(1S,2S,3R,5S)-3-(7-(((1R,2R)-2-(3-fluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质15

(1S,2S,3R,5S)-3-(7-(((1R,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-methoxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质16

2-(((3aS,4R,6S,6aR)-6-((3-((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol

替格瑞洛杂质17

(1R,2R,3S,5R)-3-((3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质18

(1S,2S,3R,5S)-3-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质19

(1S,2S,3R,5S)-3-((3-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质20

(1S,2R,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopentane-1,2,3-triol

替格瑞洛杂质21

(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质22

(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfonyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质23

sodium 7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-olate

替格瑞洛杂质24

(1S,2S,3S,5R)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质25

(1S,2S,3S,5R)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfonyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质26

2-((6-chloro-5-(7-(2-hydroxyethoxy)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2-(propylthio)pyrimidin-4-yl)oxy)ethanol

替格瑞洛杂质27

(1S,2S,3S,5R)-3-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

替格瑞洛杂质28

7-chloro-3-(4,6-dichloro-2-(propylthio)pyrimidin-5-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

替格瑞洛杂质29

(1S,2S,3R,5S)-3-(2-hydroxyethoxy)-5-(5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)cyclopentane-1,2-diol

替格瑞洛杂质30

2-(((3aR,4R,6S,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol

临床应用建议:①评估出血风险:综合考虑既往出血病史、合并出血高危疾病、现有检查结果与出血风险评分;②出血高危患者,如近期创伤/手术、凝血功能障碍、活动性或近期胃肠道出血、有活动性病理性出血、颅内出血病史或中-重度肝损害的患者禁用替格瑞洛;③有上消化道出血病史,≥75岁高龄,联用华法林、类固醇、非甾体类抗炎药,幽门螺杆菌感染的患者应合用质子泵抑制剂(PPI);④对于近期接受过冠状动脉造影、PCI、CABG或其他手术操作且服用替格瑞洛的患者,一旦出现低血压,即使未发现出血迹象,仍应怀疑出血可能;⑤替格瑞洛使用过程中发生的出血,根据出血部位及严重程度进行处理:轻微出血应尽可能采用局部压迫或药物止血,除非出血风险大于缺血风险,不建议停用替格瑞洛;严重或危及生命的出血,应停用P2Y12受体拮抗剂,在积极对症支持治疗的基础上,使用止血药物或输注血小板;出血控制后,当临床判断安全时,应尽快恢复替格瑞洛的使用。 

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